Сто наиболее значимых научных публикаций о трансплантации почки

21.02.2022
Корейские исследователи Heungman Jun и Ji Woong Hwang обратили внимание, что до настоящего времени не проводился серьезный библиометрический анализ научных публикаций, посвященных вопросам трансплантации почки. В связи с этим, они поставили перед собой задачу определить наиболее цитируемые, а, следовательно, оказавшие существенное влияние на развитие области, статьи.
Используя библиографическую базу данных Web of Science, они отобрали 93 167 статей и ранжировали их по количеству цитирований в других научных публикациях. Первую сотню подвергли углубленному анализу, результаты которого представили в журнале Medicine.
Лидером по количеству наиболее значимых статей (n = 26) стал New England Journal of Medicine. Совокупно эти 26 работ были процитированы 15 642 раза. Авторами 61 публикаций были исследователи из США, на втором месте – Канада (11 статей), на третьем – Франция (5 статей).
Иммуносупрессивная терапия, результаты трансплантаций и патология пересаженных почек были наиболее частыми темами исследований. Анализ сочетаний ключевых слов в каждой из ста работ авторы представили в виде диаграммы:
Размер каждого круга отражает частоту использования ключевого слова, а цвет – время публикации статьи.
И, конечно, главную ценность, особенно для специалистов, имеет список этих работ:
Table S1. The top 100 cited papers on KT
Rank | Article | Citations | Citation rate |
1 | The Banff 97 working classification of renal allograft pathology. Kidney International. 1999; 55: 713-23. | 2418 | 115.1 |
2 | Improved graft survival after renal transplantation in the United States, 1988 to 1996. New England Journal of Medicine. 2000; 342: 605-12. | 1402 | 70.1 |
3 | Banff 07 classification of renal allograft pathology: Updates and future directions. American Journal of Transplantation. 2008; 8: 753-60. | 1396 | 116.3 |
4 | International standardization of criteria for the histologic diagnosis of renal-allograft rejection – The banff working classification of kidney-transplant pathology. Kidney International. 1993; 44: 411-22. | 1167 | 43.2 |
5 | KDIGO clinical practice guideline for the care of kidney transplant recipients. American Journal of Transplantation. 2009; 9: S1-S155. | 1125 | 102.3 |
6 | Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal-allograft recipients. Transplantation. 1995; 60: 225-32. | 1121 | 44.8 |
7 | Reduced exposure to calcineurin inhibitors in renal transplantation. New England Journal of Medicine. 2007; 357: 2562-75. | 1094 | 84.2 |
8 | High survival rates of kidney-transplants from spousal and living unrelated donors. New England Journal of Medicine. 1995; 333: 333-6. | 880 | 35.2 |
9 | Immunosuppressive drugs for kidney transplantation. New England Journal of Medicine. 2004; 351: 2715-29. | 878 | 54.9 |
10 | A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. Transplantation. 1997; 63: 977-83. | 875 | 38 |
11 | Diabetes mellitus after kidney transplantation in the United States. American Journal of Transplantation. 2003; 3: 178-85. | 868 | 51.1 |
12 | A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. Transplantation. 1996; 61: 1029-37. | 841 | 35 |
13 | Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. American Journal of Transplantation. 2004; 4: 378-83. | 834 | 52.1 |
14 | Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. New England Journal of Medicine. 2002; 347: 488-96. | 789 | 43.8 |
15 | Antibody-mediated rejection criteria – an addition to the Banff ’97 Classification of Renal Allograft Rejection. American Journal of Transplantation. 2003; 3: 708-14. | 782 | 46 |
16 | CTLA4-Ig and anti-CD4O ligand prevent renal allograft rejection in primates. Proceedings of the National Academy of Sciences of the United States of America. 1997; 94: 8789-94. | 755 | 32.8 |
17 | Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. Lancet. 2000; 356: 194-202. | 733 | 36.7 |
18 | A study of the quality of life and cost-utility of renal transplantation. Kidney International. 1996; 50: 235-42. | 716 | 29.8 |
19 | Delayed graft function: Risk factors and implications for renal allograft survival. Transplantation. 1997; 63: 968-74. | 706 | 30.7 |
20 | Brief report: HLA-mismatched renal transplantation without maintenance immunosuppression. New England Journal of Medicine. 2008; 358: 353-61. | 704 | 58.7 |
21 | Sirolimus (rapamycin)-based therapy in human renal transplantation – Similar efficacy and different toxicity compared with cyclosporine. Transplantation. 1999; 67: 1036-42. | 703 | 33.5 |
22 | Cancer after kidney transplantation in the United States. American Journal of Transplantation. 2004; 4: 905-13. | 690 | 43.1 |
23 | Understanding the causes of kidney transplant failure: The dominant role of antibody-mediated rejection and nonadherence. American Journal of Transplantation. 2012; 12: 388-99. | 677 | 84.6 |
24 | Cancer incidence before and after kidney transplantation. Jama-Journal of the American Medical Association. 2006; 296: 2823-31. | 660 | 47.1 |
25 | Polyomavirus-associated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations. Transplantation. 2005; 79: 1277-86. | 655 | 43.7 |
26 | Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proceedings of the National Academy of Sciences of the United States of America. 1996; 93: | 652 | 27.2 |
27 | Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. New England Journal of Medicine. 1998; 338: 161-5. | 648 | 29.5 |
28 | Sirolimus for Kaposi’s sarcoma in renal-transplant recipients. New England Journal of Medicine. 2005; 352: 1317-23. | 640 | 42.7 |
29 | Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nature Medicine. 1999; 5: 686-93. | 639 | 30.4 |
30 | Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial. Lancet. 2003; 361: 2024-31. | 625 | 36.8 |
31 | Costimulation blockade with belatacept in renal transplantation. New England Journal of Medicine. 2005; 353: 770-81. | 623 | 41.5 |
32 | Medical progress – Strategies to improve long-term outcomes after renal transplantation. New England Journal of Medicine. 2002; 346: 580-90. | 620 | 34.4 |
33 | Delayed graft function in kidney transplantation. Lancet. 2004; 364: 1814-27. | 613 | 38.3 |
34 | Risk-factors for chronic rejection in renal-allograft recipients. Transplantation. 1993; 55: 752-7. | 613 | 22.7 |
35 | Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. Journal of the American Society of Nephrology. 2001; 12: 589-97. | 563 | 29.6 |
36 | Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection – A report of the European Tacrolimus Multicenter Renal Study Group. Transplantation. 1997; 64: 436-43. | 558 | 24.3 |
37 | Machine perfusion or cold storage in deceased-donor kidney transplantation. New England Journal of Medicine. 2009; 360: 7-19. | 554 | 50.4 |
38 | Randomised trial of basiliximab versus placebo for control of acute cellular rejection in renal allograft recipients. Lancet. 1997; 350: 1193-8. | 539 | 23.4 |
39 | Comparison of survival probabilities for dialysis patients vs cadaveric renal- transplant recipients. Jama-Journal of the American Medical Association. 1993; 270: 1339-43. | 533 | 19.7 |
40 | Cardiovascular disease after renal transplantation. Journal of the American Society of Nephrology. 1996; 7: 158-65. | 532 | 22.2 |
41 | A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT Study). American Journal of Transplantation. 2010; 10: 547-57. | 529 | 52.9 |
42 | Long-term survival in renal transplant recipients with graft function. Kidney International. 2000; 57: 307-13. | 528 | 26.4 |
43 | Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney International. 2002; 62: 311-8. | 525 | 29.2 |
44 | Rapid loss of vertebral mineral density after renal-transplantation. New England Journal of Medicine. 1991; 325: 544-50. | 523 | 18 |
45 | Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. New England Journal of Medicine. 2003; 349: 125-38. | 522 | 30.7 |
46 | Evolution and Clinical Pathologic Correlations of De Novo Donor-Specific HLA Antibody Post Kidney Transplant. American Journal of Transplantation. 2012; 12: 1157-67. | 510 | 63.8 |
47 | Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens. Lancet. 1998; 351: 623-8. | 504 | 22.9 |
48 | Long-term renal allograft survival in the United States: A critical reappraisal. American Journal of Transplantation. 2011; 11: 450-62. | 501 | 55.7 |
49 | Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. New England Journal of Medicine. 1999; 340: 1462-70. | 495 | 23.6 |
50 | Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. New England Journal of Medicine. 2005; 352: 558-69. | 493 | 32.9 |
51 | Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal-transplant recipients. New England Journal of Medicine. 1987; 317: 1049-54. | 488 | 14.8 |
52 | Donor characteristics associated with reduced graft survival: An approach to expanding the pool of kidney donors. Transplantation. 2002; 74: 1281-6. | 487 | 27.1 |
53 | Mycophenolate mofetil in renal allograft recipients – A pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. Transplantation. 1997; 63: 39-47. | 482 | 21 |
54 | Identifying Specific Causes of Kidney Allograft Loss. American Journal of Transplantation. 2009; 9: 527-35. | 476 | 43.3 |
55 | Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation. Journal of the American Society of Nephrology. 2010; 21: 1398-406. | 475 | 47.5 |
56 | Incidence of skin-cancer after renal-transplantatin in the Netherlands. Transplantation. 1990; 49: 506-9. | 475 | 15.8 |
57 | A randomized, placebo-controlled trial of oral acyclovir for the prevention of cytomegalo-virus disease in recipients of renal-allografts. New England Journal of Medicine. 1989; 320: 1381-7. | 475 | 15.3 |
58 | Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival. New England Journal of Medicine. 2013; 369: 1215-26. | 472 | 67.4 |
59 | A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation. 2001; 71: 271-80. | 471 | 24.8 |
60 | The effect of patients’ preferences on racial differences in access to renal transplantation. New England Journal of Medicine. 1999; 341: 1661-9. | 458 | 21.8 |
61 | Long-term renal allograft survival: Have we made significant progress or is it time to rethink our analytic and therapeutic strategies? American Journal of Transplantation. 2004; 4: 1289-95. | 456 | 28.5 |
62 | Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes – A paired donor kidney analysis. Transplantation. 2002; 74: 1377-81. | 454 | 25.2 |
63 | Cancer risk after renal-transplantation in the nordic countries, 1964-1986. International Journal of Cancer. 1995; 60: 183-9. | 452 | 18.1 |
64 | Rituximab and intravenous immune globulin for desensitization during renal transplantation. New England Journal of Medicine. 2008; 359: 242-51. | 451 | 37.6 |
65 | Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients. Transplantation. 2000; 70: 887-95. | 449 | 22.5 |
66 | Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients. Transplantation. 2000; 69: 1252-60. | 447 | 22.4 |
67 | Association of chronic kidney graft failure with recipient blood pressure. Kidney International. 1998; 53: 217-22. | 447 | 20.3 |
68 | Influence of cyclosporin pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney-transplantation. Clinical Pharmacology & Therapeutics. 1993; 54: 205-18. | 445 | 16.5 |
69 | Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. American Journal of Transplantation. 2009; 9: 2520-31. | 443 | 40.3 |
70 | Identification of a B cell signature associated with renal transplant tolerance in humans. Journal of Clinical Investigation. 2010; 120: 1836-47. | 441 | 44.1 |
71 | Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 1995; 59: 256-62. | 436 | 17.4 |
72 | Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. New England Journal of Medicine. 2001; 344: 947-54. | 429 | 22.6 |
73 | Recommendations for the outpatient surveillance of renal transplant recipients. Journal of the American Society of Nephrology. 2000; 11: S1-S86. | 428 | 21.4 |
74 | Epstein-Barr virus (EBV) induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation. Clinical, pathologic, and virologic findings and implications for therapy. Annals of Surgery. 1983; 198: 356-69. | 428 | 11.6 |
75 | Deceased-donor characteristics and the survival benefit of kidney transplantation. Jama-Journal of the American Medical Association. 2005; 294: 2726-33. | 425 | 28.3 |
76 | Racial disparities in access to renal transplantation – Clinically appropriate or due to underuse or overuse? New England Journal of Medicine. 2000; 343: 1537-U8. | 417 | 20.9 |
77 | Impact of hepatitis B and C virus on kidney transplantation outcome. Hepatology. 1999; 29: 257-63. | 416 | 19.8 |
78 | Rabbit antithymocyte globulin versus basiliximab in renal transplantation. New England Journal of Medicine. 2006; 355: 1967-77. | 414 | 29.6 |
79 | A randomized double-blind, multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation. Transplantation. 1999; 68: 261-6. | 410 | 19.5 |
80 | Effect of waiting time on renal transplant outcome. Kidney International. 2000; 58: 1311-7. | 406 | 20.3 |
81 | Cyclosporine: five years’ experience in cadaveric renal transplantation. New England Journal of Medicine. 1984; 310: 148-54. | 405 | 11.3 |
82 | Messenger RNA for FOXP3 in the urine of renal-allograft recipients. New England Journal of Medicine. 2005; 353: 2342-51. | 402 | 26.8 |
83 | Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis. Transplantation. 1995; 59: 962-8. | 399 | 16 |
84 | Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation. 2009; 87: 233-42. | 397 | 36.1 |
85 | In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts. Journal of Immunology. 1990; 144: 4604-12. | 393 | 13.1 |
86 | Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients. Transplantation. 1989; 47: 606-8. | 393 | 12.7 |
87 | Capillary deposition of C4d complement fragment and early renal graft loss. Kidney International. 1993; 43: 1333-8. | 391 | 14.5 |
88 | Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation. 1999; 67: 103-9. | 390 | 18.6 |
89 | Expanded criteria donors for kidney transplantation. American Journal of Transplantation. 2003; 3: 114-25. | 383 | 22.5 |
90 | The impact of body mass index on renal transplant outcomes: A significant independent risk factor for graft failure and patient death. Transplantation. 2002; 73: 70-4. | 378 | 21 |
91 | Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes. American Journal of Transplantation. 2011; 11: 2093-109. | 377 | 41.9 |
92 | Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. Transplantation. 2001; 72: 777-86. | 377 | 19.8 |
93 | Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries. Journal of the American Society of Nephrology. 1999; 10: 2208-14. | 375 | 17.9 |
94 | Explained and unexplained ischemic heart disease risk after renal transplantation. Journal of the American Society of Nephrology. 2000; 11: 1735-43. | 374 | 18.7 |
95 | Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation. Journal of the American Society of Nephrology. 2006; 17: 581-9. | 371 | 26.5 |
96 | Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification. Journal of the American Society of Nephrology. 2002; 13. | 370 | 20.6 |
97 | Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. New England Journal of Medicine. 2000; 342: 1309-15. | 366 | 18.3 |
98 | Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody. Transplantation. 1999; 67: 276-84. | 366 | 17.4 |
99 | Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. Journal of Clinical Investigation. 2010; 120: 1848-61. | 363 | 36.3 |
100 | Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis. Journal of the American Society of Nephrology. 2007; 18: 1046-56. | 363 | 27.9 |

Александр Игоревич Сушков
Врач-исследователь, кандидат медицинских наук, специалист в области трансплантологии.
Заведующий лабораторией новых хирургических технологий Центра хирургии и трансплантологии ФГБУ ГНЦ Федерального медицинского биофизического центра имени А.И. Бурназяна ФМБА России
Ведущий специалист ОМО по трансплантологии ГБУ "Научно-исследовательский институт организации здравоохранения и медицинского менеджмента ДЗМ"
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